Kenneth O'Byrne Selected Research

Adenocarcinoma of Lung

1/2017	EGFR mutation detection in circulating cell-free DNA of lung adenocarcinoma patients: analysis of LUX-Lung 3 and 6.
3/2016	First-Line Afatinib versus Chemotherapy in Patients with Non-Small Cell Lung Cancer and Common Epidermal Growth Factor Receptor Gene Mutations and Brain Metastases.
2/2015	Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials.
9/2013	Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations.

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Kenneth O'Byrne Research Topics

Disease

21	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 02/2020 - 05/2009
15	Neoplasms (Cancer) 01/2021 - 09/2005
7	Lung Neoplasms (Lung Cancer) 01/2018 - 01/2011
6	Neoplasm Metastasis (Metastasis) 01/2022 - 09/2005
4	Adenocarcinoma of Lung 01/2017 - 09/2013
4	Exanthema (Rash) 02/2015 - 05/2009
3	Stomatitis 02/2015 - 09/2013
3	Acne Vulgaris 02/2015 - 05/2009
3	Disease Progression 11/2012 - 07/2005
2	Pain (Aches) 01/2018 - 09/2013
2	Cough 01/2018 - 09/2013
2	Dyspnea (Shortness of Breath) 01/2018 - 09/2013
2	Melanoma (Melanoma, Malignant) 10/2017 - 04/2015
2	Adenocarcinoma 06/2017 - 03/2016
2	Fatigue 02/2015 - 09/2013
2	Neutropenia 02/2015 - 07/2005
1	Stevens-Johnson Syndrome (Lyell's Syndrome) 03/2022
1	Mesothelioma 01/2022
1	Genomic Instability 01/2021
1	Premature Aging 01/2021
1	Progeria (Hutchinson Gilford Syndrome) 01/2021
1	Colorectal Neoplasms (Colorectal Cancer) 11/2020
1	Ovarian Neoplasms (Ovarian Cancer) 01/2020
1	Chronic Disease (Chronic Diseases) 01/2019
1	Malignant Mesothelioma 11/2018
1	Prostatic Neoplasms (Prostate Cancer) 06/2017
1	Brain Neoplasms (Brain Tumor) 03/2016
1	Hypoxia (Hypoxemia) 04/2015
1	Carcinogenesis 03/2015
1	Mucositis 02/2015
1	Vomiting 02/2015
1	Paronychia 02/2015
1	Nausea 09/2013
1	Diarrhea 09/2013
1	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2011

Drug/Important Bio-Agent (IBA)

9	ErbB Receptors (EGF Receptor)IBA 06/2019 - 07/2005
7	AfatinibIBA 06/2019 - 09/2013
7	Cisplatin (Platino)FDA LinkGeneric 01/2018 - 07/2013
5	Pharmaceutical PreparationsIBA 01/2022 - 11/2014
5	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2015
4	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2014
4	PlatinumIBA 02/2017 - 05/2009
3	Erlotinib Hydrochloride (CP 358,774)FDA Link 02/2017 - 11/2012
3	Pemetrexed (MTA)FDA Link 03/2016 - 07/2013
2	pembrolizumabIBA 03/2022 - 11/2018
2	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 04/2015
2	NivolumabIBA 02/2020 - 01/2020
2	Monoclonal AntibodiesIBA 01/2020 - 05/2009
2	AntibodiesIBA 01/2020 - 04/2015
2	Carboplatin (JM8)FDA LinkGeneric 10/2017 - 01/2017
2	Immune Checkpoint InhibitorsIBA 08/2017 - 04/2015
2	onartuzumabIBA 02/2017 - 11/2012
2	LigandsIBA 05/2016 - 04/2015
1	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 01/2021
1	Thyroid Nuclear Factor 1IBA 11/2020
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 01/2020
1	GlucocorticoidsIBA 01/2020
1	Immunoglobulin G (IgG)IBA 01/2020
1	Mutant Proteins (Protein, Mutant)IBA 01/2020
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2020
1	Gefitinib (Iressa)FDA Link 06/2019
1	Tyrosine Kinase InhibitorsIBA 01/2019
1	IpilimumabIBA 10/2017
1	Paclitaxel (Taxol)FDA LinkGeneric 10/2017
1	cabazitaxel FDA Link 06/2017
1	Prostate-Specific Antigen (Semenogelase)IBA 06/2017
1	AntigensIBA 06/2017
1	Cell-Free Nucleic AcidsIBA 01/2017
1	Gemcitabine FDA Link 01/2017
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 05/2016
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 05/2016
1	Insulin-Like PeptidesIBA 09/2015
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 09/2015
1	LipidsIBA 04/2015
1	CytokinesIBA 04/2015
1	Protein Isoforms (Isoforms)IBA 03/2015
1	Heterogeneous-Nuclear Ribonucleoproteins (Informatin)IBA 03/2015
1	Pyruvate KinaseIBA 03/2015
1	Lactate Dehydrogenase 5IBA 03/2015
1	Conditioned Culture MediaIBA 03/2015
1	Small Interfering RNA (siRNA)IBA 03/2015
1	dacomitinibIBA 11/2014
1	Thymidylate SynthaseIBA 07/2013
1	Coloring Agents (Dyes)IBA 01/2011
1	Insulin (Novolin)FDA Link 01/2011
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2011
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 07/2009
1	AlbuminsIBA 07/2009
1	Cetuximab (Erbitux)FDA Link 05/2009

Therapy/Procedure

14	Therapeutics 01/2022 - 01/2011
12	Drug Therapy (Chemotherapy) 01/2018 - 05/2009
4	Immunotherapy 11/2020 - 04/2015
2	Radiotherapy 02/2020 - 12/2012
2	Time-to-Treatment 06/2019 - 07/2005
2	Combination Drug Therapy (Combination Chemotherapy) 01/2017 - 07/2009
1	Precision Medicine 01/2018
1	Aftercare (After-Treatment) 02/2017
1	Heterologous Transplantation (Xenotransplantation) 12/2012
1	Intravenous Infusions 05/2009